The cell and molecular biology of neurodegenerative disease
About the project
Together with our collaborators we analyse molecular changes associated with aging and degeneration in diseases of the motor and cognitive systems. By characterising the molecular changes associated with neurodegeneration it may be possible to understand the precise mechanisms of the pathological changes occurring in these diseases. Such understanding will inform the design in rational therapeutic interventions, and aid in the identification of valuable biomarkers specific for different phases of disease. Currently our main project focuses on ALS8, a rare inherited disorder that is caused by a mutation in a protein that appears to function in a range of fundamental cellular processes.
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Principal Investigator
Other people involved
Mark Harmon (PhD student)
Brenda Murage (PhD student)
Dr Cornelia Roesl (Post-doctoral researcher)
Prof Tom Gillingwater University of Edinburgh
Dr Christos Gkogkas, University of Edinburgh
Prof Giles Hardingham, University of Edinburgh
Prof Karen Horsburgh, University of Edinburgh
Dr Mandy Jackson, University of Edinburgh
Prof Richard Ribchester, University of Edinburgh
Dr Tom Wishart, University of Edinburgh
Prof David Wyllie, University of Edinburgh