Modelling MND using human induced pluripotent stem cells

About the project

The main focus of the Chandran lab is regenerative neurology: using patient derived iPSCs to investigate the behaviour of neurons and glial cells of the CNS in neurological diseases. We use state-of-the-art technologies, such CRISPR-Cas9 genome editing and transcriptomics, to interrogate the molecular mechanisms by which mutations in C9ORF72, the most common cause of familial ALS, and TDP43 genes affect motor neurons and the macro-glial cells of the CNS (astrocytes and oligodendrocytes). In particular, we aim to understand the intricate neuron-glial crosstalk in neurodegenerative diseases.

In addition to discovery-based research, we also undertake a translational approach wherein we use automated high-throughput phenotypic evaluation to screen for therapeutic compounds, to develop neuroprotective therapies that target the neurons, as well as the glial cells.


MND Scotland, My Name'5 Doddie Foundation, UK Dementia Research Institute, European Commission, Chief Scientist Office


Zhao, C., Devlin, A., Chouhan, A. K., Selvaraj, B. T., Stavrou, M., Burr, K., Brivio, V., He, X., Mehta, A. R., Story, D., Shaw, C. E., Dando, O., Hardingham, G. E., Miles, G. B., Chandran, S.
Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology
2019 Dec 16
Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary E, Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC, Hardingham GE, Wyllie DJ, Chandran S
Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca(2+)-permeable AMPA receptor-mediated excitotoxicity
Nat Commun. 2018 Jan 24;9(1):347

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Principal Investigator

Other people involved