A potential role for synapses in amyotrophic lateral sclerosis

About the project

My group is examining whether synapse pathology contributes to cognitive decline and the spread of pathology through the brain in ALS.  We are using the high resolution array tomography imaging technique in human post-mortem brain tissue to study synapse density and protein composition.  In our first study, we observed an association between lower synapse density in frontal cortex and cognitive impairment in ALS patients. 


MND Scotland, UK Dementia Research Institute, ERC Consolidator Award


Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, Leighton D, Warner J, Cleary E, Newton J, Swingler R, Chandran S
Gillingwater TH, Abrahams S, Spires-Jones TL
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis
Acta Neuropathol. 2018 Feb;135(2):213-226

Primary location